Cisplatin hplc method
http://www.ijsit.com/admin/ijsit_files/ijsit_1.1.5.pdf WebMar 1, 2010 · Cisplatin is an anti-tumor agent widely employed in cancer chemotherapy. A specific and selective method for the quantitative determination of cisplatin in human …
Cisplatin hplc method
Did you know?
WebWe successfully determined cisplatin, hydroxo complexes, and OH-dimer by HPLC using a πNAP column. Thus the measurement of cisplatin (cis-diamminedichloro-platinum(II), cis-[PtCl2(NH3)2]) (CDDP) should be done using a πNAP column rather than a C18 column or aminopropylsilyl silica gel column. WebJun 4, 2000 · The cisplatin recovered in the swabbing solution can be analyzed by HPLC using direct injection or preconcentration, depending on the expected level of cisplatin in the sample. Initial methods were developed to quantitate at a cisplatin concentration of about 100 PPB or higher in solution extracted from surfaces.
WebThe method was successfully applied for routine analysis of Oxaliplatin tablet dosage form and bulk drug. Key Words:Oxaliplatin, RP-HPLC, UV detection, recovery, precise, 240nm INTRODUCTION Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. oxaliplatin is the platinum-containing complex similar to cisplatin. WebNov 1, 2005 · Abstract. A method for determination of cis -diaminedichloroplatinum (II) (cisplatin) in ultrafiltered plasma, cell, and tumour samples is described. Cisplatin …
WebThe platinum content (4.91%) of Polycisplatin was determined by modified HPLC–UV method detailed in the literature. 19 Briefly, a known amount of Polycisplatin was dissolved in 0.5 M HCl solution and stirred so as to cleave the AA-Pt bond and release the cisplatin. The cisplatin was then treated with 100 µL of (10%) DDTC in 0.1 N NaOH and ... WebCisplatin was the first of the platinum-based chemotherapeutic agents and therefore has been extensively studied as an antitumor agent since the late 1960s. Because this agent …
WebCisplatin, referred to by chemical name as cis-diamminedichloroplatinum (II), is anticancer, neutral and DNA destroying agent that is square planar platinum (II) complex and contains 2 ligands of chloride in a cis configuration orientation. 1 Cisplatin has been cited as being among the most used cytotoxic anticancer medication due to its ...
WebHigh-performance liquid chromatography of cisplatin The retention behavior of cisplatin on a variety of stationary phases has been investigated using aqueous mobile phases … how many people in wales have autismWebA method of preparation and physical properties including the pK a of several species of cisplatin in water,2 the UV and visible spectra, HPLC methods, and mass spectra have been reported.1 Cisplatin is a platinum-containing, broad activity antineoplastic and alkylating agent effective against solid tumors of testes, ovaries, and bladder ... how many people in waco texasWebIn this work, a new sensitive and selective method of determining cisplatin-DNA adducts based on the use of element-selective mass spectrometry is proposed, and the method is then applied to detect cisplatin adducts induced … how can sleep disorders affect your healthWebDownload scientific diagram Cisplatin determination by HPLC method. Chromatogram shows the peak of chelating agent, diethyldithiocarbamate (DDTC), and cisplatin in … how can slavery be stoppedWebNov 1, 2008 · Purpose: The purpose of this study was to develop and validate HPLC-UV method for the determination of the cisplatin, based … how can sleep affect healthWebinjected onto the HPLC system. Retention time of cisplatin, mono-chloride, OH-dimer, and none-chloride was 3.2, 3.4, 3.6, and, 4.3–6.6 min, respectively. Measurable ranges with this method were 1˜10˚5 to 4˜10˚3 M for cisplatin. Correlation coefficient of the calibration curves of cisplatin was 0.999 (p<0.01). The within- and how can sleep apnea affect your healthWebNational Center for Biotechnology Information how can sleep affect your lifestyle