WebDec 27, 2024 · LPA-mediated CTGF induction has been reported in different cell types, including embryonic and adult fibroblasts, mesothelial cells, in human and mouse models (Heusinger-Ribeiro et al., 2001 ... WebJan 19, 2024 · (CTGF/CCN2) is a pleiotropic protein with strong profibrotic activity. In this report, we present experimental evidence showing that ECM stimulates the synthesis of CTGF in response to lysophosphatidic acid (LPA).The integrin/focal adhesion kinase (FAK) signaling pathway mediates this effect, since CTGF expression is abolished by the use of
CREB-dependent LPA-induced signaling initiates a pro-fibrotic …
WebApr 1, 2024 · Most importantly, the profibrotic effects of TGF-β and LPA are associated with the induction of connective tissue growth factor (CTGF/CCN2) (32, 68). CTGF is a highly regulated matricellular cytokine … WebFeb 4, 2024 · LPA upregulated MRTF, as expected, but did not increase CTGF. Both Cyto D and Y27632 reduced the expression of the vascular marker. Dasatinib also reduced VE-cadherin expression, but LPA failed … china\u0027s medical insurance system
Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic ...
WebMar 27, 2015 · A CArG box-like element is also enclosed in the promoter of connective tissue growth factor (CTGF, CCN2) . ... MKL1 is involved in SRE and CTGF regulation in LPA-stimulated HKC-8 cells. (A) HKC-8 cells were treated with siRNA directed against MKL1 or scrambled siRNA and then transfected with an SRE construct the following day. … WebMar 27, 2015 · The graphs summarize quantification of multiple experiments with LPA-stimulated cells set to 1 in each experiment: cellular CTGF: n = 2 ± half range; secreted … Webeton were identified as critical determinants of CTGF expression induced by LPA and 5-HT, and also by TGF-b. Connective tissue growth factor (CTGF)1 belongs to the fam-ily of low affinity insulin-like growth factor binding proteins, which consists of Mac25, the nov oncogenes, and cyr61 (1), and is also classified as a member of the CCN (CYR61 ... china\\u0027s mars rover