WebUniProtKB. x; UniProtKB. Protein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. WebAug 5, 2024 · Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced …

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WebNX_Q9BZC1 - CELF4 - CUGBP Elav-like family member 4 - Function. RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of … WebJul 26, 2013 · The deduced protein contains 2 N-terminal RNA-recognition motifs (RRMs), a long linker region, and a C-terminal RRM. By searching EST databases for sequences similar to CUGBP ( 601074 ), followed by PCR of a human brain cDNA library, Ladd et al. (2001) cloned BRUNOL5, which they called CELF5. In addition to the RRMs, the … dan fahey climateworks

CUGBP1 - Wikipedia

WebNX_O95319 - CELF2 - CUGBP Elav-like family member 2 - Function. RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative … The demonstration that hCUGBP1 is involved in the control of mRNA deadenylation and instability like xCUGBP1 came next. In mammalian cell extract as well as in xenopus egg extracts, depletion and rescue experiments showed that specific binding of CUGBP1 to the 3'UTR of mRNA is required for the targeted … See more CUG triplet repeat, RNA binding protein 1, also known as CUGBP1, is a protein which in humans is encoded by the CUGBP1 gene. See more Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM … See more • Human CELF1 genome location and CELF1 gene details page in the UCSC Genome Browser. See more It is estimated that 5 to 8% of human mRNAs are unstable because of mRNA instability elements in their 3' untranslated regions (3'UTR). A number of such elements have … See more • Timchenko LT, Timchenko NA, Caskey CT, Roberts R (1996). "Novel proteins with binding specificity for DNA CTG repeats and RNA CUG repeats: implications for myotonic dystrophy" See more WebJul 5, 2024 · Primary sensory Dorsal Root Ganglia (DRG) neurons are diverse, with distinct populations that respond to specific stimuli. Previously, we observed that functionally distinct popul danez smith don\u0027t call us dead