Flvcr2 heme
Web(Click on the icon in the table below to see search hit context) WebFlvcr2 Gene Detail Summary Symbol Flvcr2 Name feline leukemia virus subgroup C cellular receptor 2 Synonyms CCT, Mfsd7c, MGC:19050 Feature Type protein coding gene IDs MGI:2384974 NCBI Gene: 217721 Alliance gene page Transcription Start Sites 5 TSS Location & Maps more Sequence Map Chr12:85793313-85860359 bp, + strand From …
Flvcr2 heme
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WebApr 1, 2013 · FLVCR2 is highly homologous to FLVCR1 and may function as a cellular heme importer. Mutations of SLC49A2 encoding FLVCR2 are observed in Fowler syndrome, a rare proliferative vascular disorder of the brain. The functions of the remaining members of the SLC49 family, MFSD7 and DIRC2 (encoded by the SLC49A3 and … WebApr 24, 2024 · By candidate gene sequencing, Meyer et al. (2010) identified a homozygous mutation in the FLVCR2 gene (T430R; 610865.0001) in 5 fetuses with PVHH from 3 consanguineous Pakistani families.Two additional fetuses of northern European origin with the disorder were each found to be compound heterozygous for 2 mutations in the …
WebJul 1, 2007 · FLVCR2 (FLVCR heme transporter 2) 2007-07-01 Identity HGNC FLVCR2 LOCATION 14q24.3 LOCUSID 55640 ALIAS C14orf58, CCT, EPV, FLVCRL14q, … WebDec 7, 2024 · Heme (iron protoporphyrin IX) is a major toxic component of hemoglobin released from red cell turnover especially during intravascular hemolysis such as in sickle cell disease, malaria and paroxysmal nocturnal hemoglobinuria.
WebNM_017791.3(FLVCR2):c.543G>A (p.Val181=) AND not specified Clinical significance: Benign (Last evaluated: Jul 3, 2013) Review status: 1 star out of maximum of 4 stars WebSep 7, 2010 · ABSTRACT Mutations in FLVCR2, a cell surface protein related by homology and membrane topology to the heme exporter/retroviral receptor FLVCR1, have recently been associated with Fowler syndrome, a vascular disorder of the brain. We previously identified FLVCR2 to function as a receptor for FY981 feline leukemia virus (FeLV).
WebAug 1, 2024 · Leishmania has a putative homologue of the human heme importer FLVCR2. Human FLVCR2 (NP_060261.2), which has been reported to be a heme importer located on the plasma membrane of mammal cells [], was used as a template to identify putative homologs in trypanosomatid parasites by way of a BLAST analysis.Four potential …
WebFeline leukemia virus subgroup C cellular receptor family, member 2 is a protein that in humans is encoded by the FLVCR2 gene. Function. This gene encodes a member of the … greenwich university eventsWebMutations in FLVCR2, a cell surface protein related by homology and membrane topology to the heme exporter/retroviral receptor FLVCR1, have recently been associated with Fowler syndrome, a... greenwich university englishWebApr 24, 2024 · The FLVCR2 gene encodes a transmembrane protein that belongs to the major facilitator superfamily of secondary carriers that transport small solutes in … foam flinging shotgunWebNov 1, 2010 · Here, we report the cellular function of FLVCR2 as an importer of heme, based on the following observations. First, FLVCR2 binds to hemin-conjugated agarose, and binding is competed by free... greenwich university exam timetableWebSYNDROME PROTEIN FLVCR2 IS A HEME IMPORTER 5319 and colleagues (37) (Fig. 2C). These results collectively indicate that huFLVCR2 is an importer of heme. greenwich university entry requirementsWebNM_017791.3(FLVCR2):c.648C>G (p.Ser216=) AND not provided Clinical significance: Benign (Last evaluated: Nov 1, 2024) Review status: 2 stars out of maximum of 4 stars foam flightWebFinally, cells overexpressing FLVCR2 are more sensitive to heme toxicity, a finding most likely attributable to enhanced heme uptake. Tissue expression analysis indicates that … foam flipbook texture