Tachyphylaxis with desmopressin
WebDesmopressin is an analog of vasopressin that exerts a substantial haemostatic effect by inducing the release of von Willebrand factor from its storage sites in endothelial cells. It … WebApr 26, 2024 · Stimate (Desmopressin Acetate Nasal Spray) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. ... The tendency toward tachyphylaxis (lessening of response) with repeated administration given more frequently than once every 48 hours ...
Tachyphylaxis with desmopressin
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WebTachyphylaxis is characterized by the rate sensitivity: the response of the system depends on the rate with which a stimulus is presented. To be specific, a high-intensity prolonged … WebAims: To study desmopressin response in hemophilia A patients who received repeated doses perioperatively and to determine extent and determinants of tachyphylaxis. …
WebDesmopressin (1-deamino-8-d -arginine vasopressin (DDAVP)) is a synthetic analogue of the antidiuretic hormone 8-arginine vasopressin. DDAVP stimulates the vasopressin V2 receptor, which causes water retention and the release of FVIII and vWF from endothelium. DDAVP has been used in mild hemophilia and type I vWD (decreased multimers of vWF). WebSummary When patients with mild haemophilia or von Willebrand disease (vWD) are repeatedly treated with desmopressin (DDAVP) at relatively short time intervals, some of them may become less responsive or unresponsive. The development of tachyphylaxis would limit the usefulness of DDAVP in clinical management of these patients.
WebTachyphylaxis (lessening of response) with repeated administration (i.e., given more frequently than every 48 hours) may occur. The initial response is reproducible if ... Desmopressin acetate injection, USP is available as a sterile solution supplied in carton of ten 1 mL single-dose, type I glass vials with rubber stopper and aluminium seal ... WebThe mechanism(s) for tachyphylaxis has not been investigated. The aims of this study are: a) to investigate the effect of repeated DDAVP infusion on the behaviour of FVIII, vWF, t …
WebSep 30, 2024 · Desmopressin Acetate Injection USP is a vasopressin analog used for: Central Diabetes Insipidus - as antidiuretic replacement therapy in the management of …
WebDDAVP (desmopressin), either intravenously or by nasal spray (Stimate), is often helpful for patients with a platelet function defect (see Chapter 67 for details). There should be a … nagi and reo goal against musterdWebmoderate disease, on-demand treatment with desmopressin is an effective option for raising endogenous VWF levels. As such, des-mopressin and/or tranexamic acid are often used for minor surgical procedures, including dental work. 5,7 In some patients, the response to desmopressin decreases after repeated doses (tachyphylaxis) with reduced ... medigap plan rate comparisonWebApr 9, 2024 · Ferraris VA, Boral LI, Cohen AJ, Smyth SS, White GC 2nd. Consensus review of the treatment of cardiovascular disease in people with hemophilia A and B. Cardiol Rev. 2015 Mar-Apr;23(2):53-68. doi: 10.1097/CRD.0000000000000045. nagib a.for engineering and tradingWebDesmopressin. 423 Parenteral desmopressin was originally formulated at a concentration of 4 μg/mL, to be used at a 0.3-μg/kg/dose to treat bleeding diatheses such as hemophilia A and von Willebrand disease type 1. ... but tachyphylaxis may occur after three or four doses, 37 limiting further usefulness of DDAVP. medigap plans comparison chart 2022Webdeveloping tachyphylaxis. Plasma-derived VWF/FVIII concentrates These products, with the characteristics summa-rized in Table 1, are recommended at the dosages shown in Table 26 in cases with no or inadequate response to DDAVP. Table 3 summarizes data on the efficacy of VWF/FVIII for short-term bleeding prophylaxis in patients undergoing surgery or nagiahs trading hoursWebAnaphylaxis has been reported rarely with intravenous and intranasal desmopressin acetate, including isolated cases of fatal anaphylaxis with intravenous desmopressin acetate. It is not known whether antibodies to Desmopressin Acetate Injection 4 mcg/mL are produced after repeated injections. medigap plan n rate increasesWebSep 1, 2024 · Tachyphylaxis (lessening of response) with repeated administration (i.e., given more frequently than every 48 hours) may occur. The initial response is reproducible if DDAVP is administered every 2 to 3 … nagib abboud netcracker